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Publications

Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination

Fatima Amer-SarsourDaniel FalikYevgeny BerdichevskyAlina KordonskySharbel EidTatiana RabinskiHasan IshtayehStav Cohen-AdivItzhak BravermanSergiu C BlumenTal LavivGali PragGad D VatineAvraham Ashkenazi.

THE EMBO JOURNAL

https://doi.org/10.1038/s44318-023-00018-9

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Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease

Mor Sela Maria Poley , Patricia Mora-Raimundo , Shaked Kagan , Aviram Avital , Maya Kaduri Gal Chen , Omer AdirAdi Rozencweig , Yfat Weiss , Ofir Sade , Yael Leichtmann-BardoogoLilach SimchiShlomit Aga-Mizrachi , Batia Bell , Yoel Yeretz-Peretz , Aviv Zaid Or , Ashwani Choudhary , Idan Rosh , Diogo Cordeiro , Stav Cohen-Adiv , Yevgeny Berdichevsky , Anas Odeh , Jeny Shklover , Janna Shainsky-Roitman , Joshua E Schroeder , Dov Hershkovitz , Peleg HassonAvraham Ashkenazi Shani Stern , Tal Laviv , Ayal Ben-Zvi , Avi Avital , Uri Ashery , Ben M Maoz , Avi Schroeder 

ADVANCED MATERIALS

10.1002/adma.202304654

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Imaging neuronal protein signaling dynamics in vivo

 

Tal Laviv* and Ryohei Yasuda* 

*Co-corresponding authors

Current Opinion in Neurobiology 2021

https://www.sciencedirect.com/science/article/pii/S095943882100012X?via%3Dihub

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Methodologies and Challenges for CRISPR/Cas9 Mediated Genome Editing of the Mammalian Brain

 

Hirofumi Nishizono*Ryohei Yasuda* and Tal Laviv*

*Co-corresponding authors

Frontiers in Genome Editting 2020

https://www.frontiersin.org/articles/10.3389/fgeed.2020.602970/full

Our recent review summerizing the state of the art in the field of genome editting in the mammalian brain 

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In Vivo Imaging of the Coupling between Neuronal and CREB Activity in the Mouse Brain

 

Tal Laviv, Benjamin Scholl, Paula Parra-Bueno, Beth Foote, Chuqiu Zhang, Long Yan
Yuki Hayano, Jun Chu, Ryohei Yasuda#
# Co-corresponding author

 

Neuron 2020

https://pubmed.ncbi.nlm.nih.gov/31883788/

Here we generated new CREB biosensors, which allowed us to simultaneously monitor CREB and neuronal activity dynamics in awake mice

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Here we engineered new red fluorescent proteins which allow dual two-photon fluorescent lifetime imaging  

Simultaneous dual-color fluorescence lifetime imaging with novel red-shifted fluorescent proteins

 

Tal Laviv, Benjamin B Kim, Jun Chu, Amy J Lam, Michael Z Lin and Ryohei Yasuda 

Nature Methods 2016

https://www.nature.com/articles/nmeth.4046

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