Publications
Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain
Tomer Kagan, Matan Gabay, Aasha Meenakshisundaram, Yossi Levi, Sharbel Eid, Nikol Malchenko, Maya Maman, Anat Nitzan, Luca Ravotto, Ronen Zaidel-Bar, Britta Johanna Eickholt, Maayan Gal & Tal Laviv
NATURE METHODS 2025
https://www.nature.com/articles/s41592-025-02610-9#citeas
Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice
Wenwen Li, Jiarui Li, Jing Li, Chen Wei, Tal Laviv, Meiyi Dong, Jingran Lin, Mariah Calubag , Lesle A Colgan, Kai Jin Bing Zhou, Ying Shen, Haohong Li , Yihui Cui, Zhihua Gao, Tao Li, Hailan Hu, Ryohei Yasuda, and Huan Ma
SCIENCE 2024
https://www.science.org/doi/10.1126/science.adp6547
Disease-associated polyalanine expansion mutations
impair UBA6-dependent ubiquitination
Fatima Amer-Sarsour, Daniel Falik, Yevgeny Berdichevsky, Alina Kordonsky, Sharbel Eid, Tatiana Rabinski, Hasan Ishtayeh, Stav Cohen-Adiv, Itzhak Braverman, Sergiu C Blumen, Tal Laviv, Gali Prag, Gad D Vatine, Avraham Ashkenazi.
THE EMBO JOURNAL
https://doi.org/10.1038/s44318-023-00018-9
Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease
Mor Sela , Maria Poley , Patricia Mora-Raimundo , Shaked Kagan , Aviram Avital , Maya Kaduri , Gal Chen , Omer Adir, Adi Rozencweig , Yfat Weiss , Ofir Sade , Yael Leichtmann-Bardoogo, Lilach Simchi, Shlomit Aga-Mizrachi , Batia Bell , Yoel Yeretz-Peretz , Aviv Zaid Or , Ashwani Choudhary , Idan Rosh , Diogo Cordeiro , Stav Cohen-Adiv , Yevgeny Berdichevsky , Anas Odeh , Jeny Shklover , Janna Shainsky-Roitman , Joshua E Schroeder , Dov Hershkovitz , Peleg Hasson, Avraham Ashkenazi , Shani Stern , Tal Laviv , Ayal Ben-Zvi , Avi Avital , Uri Ashery , Ben M Maoz , Avi Schroeder
ADVANCED MATERIALS
10.1002/adma.202304654
Tension-dependent RHGF-1 recruitment to stress fibers drives robust spermathecal tissue contraction
JBC - Journal of Cell Biology
https://rupress.org/jcb/article/222/2/e202203105/213784/Tension-dependent-RHGF-1-recruitment-to-stress
Imaging neuronal protein signaling dynamics in vivo
Tal Laviv* and Ryohei Yasuda*.
Current Opinion in Neurobiology 2021
https://www.sciencedirect.com/science/article/pii/S095943882100012X?via%3Dihub
Methodologies and Challenges for CRISPR/Cas9 Mediated Genome Editing of the Mammalian Brain
Hirofumi Nishizono*, Ryohei Yasuda* and Tal Laviv*
Frontiers in Genome Editting 2020
https://www.frontiersin.org/articles/10.3389/fgeed.2020.602970/full
Our recent review summerizing the state of the art in the field of genome editting in the mammalian brain
In Vivo Imaging of the Coupling between Neuronal and CREB Activity in the Mouse Brain
Tal Laviv, Benjamin Scholl, Paula Parra-Bueno, Beth Foote, Chuqiu Zhang, Long Yan
Yuki Hayano, Jun Chu, Ryohei Yasuda*
*Co-corresponding author
Neuron 2020
https://pubmed.ncbi.nlm.nih.gov/31883788/
Here we generated new CREB biosensors, which allowed us to simultaneously monitor CREB and neuronal activity dynamics in awake mice
Simultaneous dual-color fluorescence lifetime imaging with novel red-shifted fluorescent proteins
Tal Laviv, Benjamin B Kim, Jun Chu, Amy J Lam, Michael Z Lin and Ryohei Yasuda
Nature Methods 2016
https://www.nature.com/articles/nmeth.4046
Here we engineered new red fluorescent proteins which allow dual two-photon fluorescent lifetime imaging